Results Of Kidney Transplantation In HIV-Infected Patients
01/09/2013 22:09
Results Of Kidney Transplantation In HIV-Infected Patients.
A large, supplemental examination provides more trace that settle infected with HIV, the virus that causes AIDS, do almost as well on the survival leading as other patients when they undergo kidney transplants. Up until the mid-1990s, physicians tended to refrain from giving kidney transplants to HIV patients because of tremble that AIDS would at kill them vimax. Since then, restored medications have greatly lengthened fixation spans for HIV patients, and surgeons routinely work kidney transplants on them in some urban hospitals.
The survey authors, led by Dr Peter G Stock, a professor of surgery at the University of California, San Francisco, examined the medical records of 150 HIV-infected patients who underwent kidney transplantation between 2003 and 2009. They publish their findings in the Nov pill larder. 18 appear of the New England Journal of Medicine.
The researchers found that about 95 percent of the relocate patients lived for one year and about 88 percent lived for three years. Those survival rates destruction between those for kidney displace patients in ill-defined and those who are grey 65 and over. "They living just as wish as the other patients we examine for transplantation. They're essentially the same as the calm of our patients," said move authority Dr Silas P Norman, an underling professor of internal medication at the University of Michigan. Norman was not part of the look at team.
There was one troubling finding: the bodies of HIV patients were more promising to reject the kidneys than the bodies of other shift patients. It's likely that surgeons will exigency to better tailor their procedures to help frustrate organ rejection, said transplant surgeon Dr Dorry Segev. This should happen as surgeons glean more endure with transplants in HIV patients, said Segev, an fellow-worker professor of surgery and epidemiology at Johns Hopkins Medical Institutions, who was palsy-walsy with the muse about findings.
Overall, Segev said, "treatment of HIV-infected patients undergoing kidney transplantation is starkly not straightforward, and this studio has identified some challenges for the remove community to address". On the flashing side, transplant procedures didn't appear to have much of an thrust on the HIV infections in the patients.
In years past, Norman said, resettle surgeons agonizing about how the AIDS virus would interact with the medications given to uproot patients that are designed to dampen the exempt system. The concern was that "these patients are now doing well, and you're customary to give them medicine and unhook all their benefits," he said.
But it turns out that transplantation drugs have the differing effect and often suppress the AIDS virus, he said. This is because HIV revs up the protected set while the drugs turn it down, he explained. Norman said he expects that the recent findings will pep up more surgeons to perform kidney transplants on HIV patients, who are time and surviving hanker enough to develop diseases that typically target older people. "There are still a lot of clan in the community, including transfer professionals, nephrologists and infectious ailment professionals, who still don't appreciate that many of these patients are favourable prospects for transplantation," Norman said online. "They don't rate how many procedures have been done to date, and how we're getting overall very saintly outcomes".
A large, supplemental examination provides more trace that settle infected with HIV, the virus that causes AIDS, do almost as well on the survival leading as other patients when they undergo kidney transplants. Up until the mid-1990s, physicians tended to refrain from giving kidney transplants to HIV patients because of tremble that AIDS would at kill them vimax. Since then, restored medications have greatly lengthened fixation spans for HIV patients, and surgeons routinely work kidney transplants on them in some urban hospitals.
The survey authors, led by Dr Peter G Stock, a professor of surgery at the University of California, San Francisco, examined the medical records of 150 HIV-infected patients who underwent kidney transplantation between 2003 and 2009. They publish their findings in the Nov pill larder. 18 appear of the New England Journal of Medicine.
The researchers found that about 95 percent of the relocate patients lived for one year and about 88 percent lived for three years. Those survival rates destruction between those for kidney displace patients in ill-defined and those who are grey 65 and over. "They living just as wish as the other patients we examine for transplantation. They're essentially the same as the calm of our patients," said move authority Dr Silas P Norman, an underling professor of internal medication at the University of Michigan. Norman was not part of the look at team.
There was one troubling finding: the bodies of HIV patients were more promising to reject the kidneys than the bodies of other shift patients. It's likely that surgeons will exigency to better tailor their procedures to help frustrate organ rejection, said transplant surgeon Dr Dorry Segev. This should happen as surgeons glean more endure with transplants in HIV patients, said Segev, an fellow-worker professor of surgery and epidemiology at Johns Hopkins Medical Institutions, who was palsy-walsy with the muse about findings.
Overall, Segev said, "treatment of HIV-infected patients undergoing kidney transplantation is starkly not straightforward, and this studio has identified some challenges for the remove community to address". On the flashing side, transplant procedures didn't appear to have much of an thrust on the HIV infections in the patients.
In years past, Norman said, resettle surgeons agonizing about how the AIDS virus would interact with the medications given to uproot patients that are designed to dampen the exempt system. The concern was that "these patients are now doing well, and you're customary to give them medicine and unhook all their benefits," he said.
But it turns out that transplantation drugs have the differing effect and often suppress the AIDS virus, he said. This is because HIV revs up the protected set while the drugs turn it down, he explained. Norman said he expects that the recent findings will pep up more surgeons to perform kidney transplants on HIV patients, who are time and surviving hanker enough to develop diseases that typically target older people. "There are still a lot of clan in the community, including transfer professionals, nephrologists and infectious ailment professionals, who still don't appreciate that many of these patients are favourable prospects for transplantation," Norman said online. "They don't rate how many procedures have been done to date, and how we're getting overall very saintly outcomes".